Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the commonest enzymatic disorder of red blood cells which affects approximately 400 million people worldwide. It is a X-linked recessive disorder affecting males more with highest prevalence in Africa, Southern Europe, Middle East and South East Asia. ...
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have been a significant advance in the treatment of hormone receptor-positive, HER2-negative metastatic breast cancer, leading to the approval of three different CDK4/6 inhibitors (palbociclib, ribociclib, and abemaciclib) in both first- and second-line indications [1-5,9]. ...
Left atrial appendage (LAA) is a finger-like muscular extension of the left atrium (LA). It acts as blood reservoir, modulates LA pressure and elicits adaptive responses to stress. Several LAA shapes and variants have been described. We report a rare case of congenital absence of LAA diagnosed by trans-esophageal echocardiography (TEE) and confirmed by computed tomography (CT) in a 55-year-old patient. ...
Hibernomas are rare benign neoplasms that develop from fetal brown fat. They were first described under the name 'pseudolipoma' by the German physician H. Merkel in 1906 and the term hibernoma was proposed by the French anatomist Louis Gery in 1914 because of its resemblance to brown fat in hibernating animals [3,4]. ...
Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant neoplasm affecting mesenchymal tissue. It comprises less than 3% of all adult soft tissue tumors [1]. Whereas EMC was initially classified as a low-grade sarcoma with indolent clinical course, long-term follow-up studies have emphasized its resilient nature with a significant potential for metastatic progression [2]. ...
Seromas are one of the most common surgical complications surgeons encounter with rates as high as 38% for abdominal procedures [1] and 20% groin surgery [9,10]. Despite relatively high rate of seromas that surgeons encounter there is currently no gold standard for treatment. ...
Melanosis coli (MC) is a condition characterized by a brown to black discoloration of the colon [1]. It is associated with long term use of anthraquinone-containing laxatives in people with chronic constipation [1]. MC itself has no symptoms and it is frequently diagnosed incidentally during lower gastrointestinal endoscopy or during abdominal surgery. ...
Leishmaniasis is caused by the protozoa leishmania, whose reservoirs are mammals, and its vector is the Phlebotomus mosquito. The world`s annual incidence is 700,000 cases per year and it is more common among immunocompromised and young infants. It is endemic in tropical and subtropical areas, and southern Europe, being more frequent in rural areas; however, it has been described in urban suburbs [1]. ...
The function of the thyroid gland is very important for metabolic processes including basal metabolic rate, nervous reflexes, temperature regulation, cardiac contractility, intestinal transit and growth and maturation processes of tissues and organs [1]. Therefore, the thyroid affects the function of virtually all organs and systems. ...
Here we report a case of a young pregnant women presenting in her second trimester with Adult Onset Still's Disease (AOSD) complicated by Macrophage Activation Syndrome (MAS). AOSD is a systemic autoinflammatory process which classically manifests as fevers, arthralgias, pink maculopapular rash, along with lymphadenopathy and hepatosplenomegaly [1]. ...
A 3-year-old boy with a significant language delay and a history of repeated acute otitis media presented with pruritic, yellowish-crusted plaques on the scalp and erythematous excoriated papules on the trunk (Figure 1). Concurrently, the patient experienced polyuria, polydipsia (up to six liters per day), anorexia, and asthenia. ...
Methadone, a synthetic human μ-opioid receptor (hMOR) agonist, is used for the management of pain as well as a maintenance treatment drug for opioid dependent patients [1,2]. It is metabolized by the P450 enzymes CYP1A2, CYP2B6 and CYP2C1 in the liver. ...
Endometriosis is a chronic, multifactorial disease of unknown etiology that affects approximately 10% of all women of childbearing age. Its prevalence, although difficult to estimate precisely, may exceed that of diabetes mellitus or breast cancer. It is estimated that in Spain there are one million women affected by endometriosis. ...
Hand, foot, and mouth disease (HFMD) Is a relatively common viral infection that predominantly affects young children, usually during the spring and fall months [1]. It is caused by members of the human enterovirus (HEV) Genus that belong to the Picornaviridae family, specifically human enteroviruses and coxsackieviruses [2]. ...
Endometriosis occurs when endometrial tissue, typically found inside the uterus, spreads to areas outside the uterus, such as the peritoneum, ovaries, and rectovaginal septum. This condition impacts around 10-15% of women during their reproductive years and about 35-50% of women dealing with pelvic pain and/or infertility [2]. ...
Hemophilia A is a congenital bleeding disorder resulting by deficiency of coagulation factor VIII, with a prevalence of approximately 23 per 100.000 live male births [1]. Acute Lymphoblastic Leukemia (ALL) is the most common cancer type in children. The concurrence of hemophilia and ALL in pediatric patients is even more rare and particularly challenging due to the specific clinical problems it poses. ...
It is usually said that aspiration is a kind of complications caused by gravity or indwelling a gastric tube in the esophagus after anesthesia, however, it is also one common fatal complication in elderly patients, especially for those bedridden. Here we provided 3 cases which occurred recently in our hospital. Unfortunately two of them passed out soon after aspiration. ...
Monochorionic twins are prone to a variety of complications due to vascular abnormality of the single placenta supplying the twin. These complications include twin-twin transfusion syndrome, twin anaemia/polycythaemia, twin reversed arterial perfusion sequence amongst others [1-3]. ...
Rotavirus is in the family Reoviridae and is a genus of double-stranded RNA viruses [1]. The viral particle has three layers covering the genome. With the outermost shell containing two important proteins: VP7, or G-protein, and VP4, or P-protein. VP7 and VP4 induce neutralizing antibodies that are thought to be involved in immune protection [2]. ...
Peer review is an essential process in any publications refereeing a mutual process that allows evaluating manuscripts submitted to a journal and commented upon by independent research experts within the similar field of research...
Open Access is the free of charge, instant, online availability of research articles, together with the rights to use these articles fully in the digital milieu. It provides unrestricted use and reuse...
Plagiarism is a part of Journalistic ethic where it is considered to be a crime. The act of taking content, writing, statement or an idea that is already published is known as plagiarism. Whenever you consider using any paraphrase, sum up, or take terms, phrases, sentences or statements...