Coronary artery fistulas are abnormal vascular communications in which blood is shunted bypassing the myocardial capillary network into the cardiac chambers or any segment of systemic or pulmonary circulation affecting hemodynamic parameters [1]. Coronary cameral fistula (CCF) detected in adulthood is associated with an increased risk of heart failure, myocardial ischemia, infective endocarditis ...
Desmoid Fibromatosis (DF) is locally aggressive benign fibroblastic or myofibroblastic tumor with no metastatic potential, but has high recurrence rate. It is a rare disease accounting 3% of all soft tissue tumors. There are reported two relatively peaks of the disease occurrence: one between 6-15 years and one between puberty and 40. The symptoms vary according to tumor location. Abdominal ...
Leadless pacemakers offer an alternative to conventional transvenous pacing systems, particularly for patients at an increased risk of infection or with limited venous access [1-3]. First-generation leadless pacemakers were only capable of single-chamber ventricular pacing, which significantly limited their potential indications. To widen the spectrum of patients who qualify for leadless pacing, a second ...
Klingsor syndrome, also known as self-inflicted traumatic penile amputation, is a rare condition that often occurs in individuals who suffer from psychiatric disorders, religious preoccupations, substance abuse, and societal neglect or isolation. This condition is a urological emergency that requires immediate and prompt attention. Despite its rarity, the management of Klingsor syndrome is crucial for optimal ...
Since the using of anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA-4) in the treatment of melanoma, the immune checkpoint inhibitors (ICIs) had achieved many impressive successes in the field of cancer immunotherapy. The antibodies against programmed cell death 1 (PD-1) and its ligand (PD-L1) had brought patients with durable responses and extension of survival [1]. The PD-1 and PD-L1 ...
Hypoglossal nerve palsy is a rare clinical condition that can provoke characteristic clinical signs, including hemi-atrophy, fasciculations and deviation of the tongue. It is commonly presented with other cranial nerve palsies. The most common cause is a tumor, predominantly malignant, as described in nearly half of the palsies, thus emphasizing the need to exclude malignancies [1], followed by trauma ...
As many as 70% of bladder injuries are associated with pelvic fractures. In most cases however, bone fragments are usually not directly responsible for bladder injury. It is usually the compressive and sheer forces of blunt trauma tear tissues attached to the extraperitoneal portions of the bladder, or the abrupt increase in intravesical pressure which causes the bladder dome to burst into. ...
Arterial Thromboembolism (TE), is due to a heterogeneous group of disorders that associate with faulty hemostasis with consequent vascular thrombosis and embolism [1], the sequel of the latter are sometimes lethal. The arterial TE disorders including prosthetic valves, are predominantly presented by atrial fibrillation (AF) and strokes [2]. Though, the management of the primary disorder is a target ...
Attention deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type [1,2], characterized by difficulty paying attention, excessive activity, and behavior without regards to consequences which is not appropriate for a person's age [3,4]. It also comes with problem regulating ...
Osteochondroma or Exestosis are the most common benign bone tumor that mostly arises from long bones metaphysic. They could be sessile or pedenculated and always covered by cartilaginous cap. They occurs more often in children and stops growing in adulthood; they could be isolated or being part of hereditary disease with multiple location. Tumor size and location are the most important factors ...
Schizophrenia is a severe psychiatric disorder that affects millions of people worldwide. It is characterized by a range of symptoms, including positive symptoms such as delusions and hallucinations, and negative symptoms such as blunted affect and reduced motivation. The diagnosis of schizophrenia is challenging and can often be delayed, which can result in inadequate treatment and poor patient outcomes ...
Siffert and Arkin described the first case of distal tibial osteochondrosis in 1950 [1]. Since then, nine other cases were reported. The pathophysiology of this rare condition is still debated and is likely multifactorial. The clinical presentation is not specific but imaging findings are characteristic and worth to be known. Magnetic Resonance Imaging (MRI) represents the key tool for diagnosis. ...
Sarcopenia is an emerging public health issue affecting a majority of the aging population worldwide. With the loss of muscle strength, mass, and poor physical performance, sarcopenia shows multiple clinical manifestations like frailty. Therefore, it is regarded as a major component of frailty. Furthermore, sarcopenia and frailty lead to poor prognosis, loss of independent movements, shorter health ...
According to the 2018 global cancer statistics, hepatocellular carcinoma (HCC) is the sixth most common malignancy and the fourth leading cause of cancer-related mortality [1,2]. Despite recent advances in HCC treatment, the outcomes are far from satisfactory [3,4]. Therefore, there is an urgent need to identify novel therapeutic targets and diagnostic biomarkers of HCC in order to improve patient prognosis. ...
The exact aetiological factors for the Chronic Kidney Disease (CKDu) found in Sri Lanka are still unresolved. The disease is reported in epidemic proportion in certain geographical areas and considered to be a public health concern as it is associated with low life expectancy, catastrophic health expenditure and serious social consequences. A similar clinical entity is reported world-wide ...
Peer review is an essential process in any publications refereeing a mutual process that allows evaluating manuscripts submitted to a journal and commented upon by independent research experts within the similar field of research...
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Plagiarism is a part of Journalistic ethic where it is considered to be a crime. The act of taking content, writing, statement or an idea that is already published is known as plagiarism. Whenever you consider using any paraphrase, sum up, or take terms, phrases, sentences or statements...