Neurological pathology is considered rare but serious complications after allogeneic Hematopoietic Stem Cell Transplantation (allo HSCT). The presented case report shows it poses a diagnostic challenge for physicians and a great threat for patients. A 64-year-old patient was admitted to the hospital due to progressive alteration of consciousness for three weeks. Sixty days prior, the patient had undergone an allo-HSCT due to high-risk Acute Lymphoblastic Leukemia (ALL) with initial infiltration of Cerebrospinal Fluid (CSF). ...
During the COVID-19 pandemic, patients go to the emergency room of hospitals and health centers, and the first thing doctors do, is think about the SARS-CoV-2 infection, forgetting about alternative diagnoses, which leads to an over diagnosis of this infection and an under diagnosis of other pathologies, ...
Cardiovascular syphilitic lesions in tertiary syphilis can manifest as aortitis, formation of an aneurysm, aortic root dilatation, aortic regurgitation, and coronary ostial stenosis [1,2]. Aortitis is the most common cardiovascular complication of untreated late syphilis [3]. We outline a case of an unusual ...
A Seventy-four years old male presented to the Emergency Department (ED) with three days' pain, and large skin hematoma in the medial aspect of his left thigh, started when he stepped out of his car and felt sharp pain in his left groin. ...
Subcutaneous emphysema is the presence of air in subcutaneous tissues and can be the result of numerous etiologies. Non-infectious subcutaneous emphysema can have many causes including trauma, surgery, and perforation [1]. Compared to necrotizing soft tissue infections, pain is usually not out-of-proportion ...
Thyrotoxic Periodic Paralysis (TPP) is a rare disorder characterized clinically by the appearance of repeated episodes of paralysis associated with hypokalaemia and thyrotoxicosis [1-3]. TPP is triggered by a state of thyrotoxicosis. The most frequently associated disease is Graves' disease but any disease that ...
Severe pneumonia with respiratory failure requiring ventilatory support carries a high mortality worldwide [1]. Early administration of antimicrobial agents will make a difference in outcome giving best results [2]. Accurate identification of causative organism plays a pivotal role in antibiotic stewardship ...
Peripartum Cardiomyopathy (PPCM) affects 1 in 1000 pregnancies worldwide and accounts for 25% to 30% of maternal deaths [1]. PPCM is classified as heart failure occurring in the last month of pregnancy or postpartum with a left ventricular systolic dysfunction with an Left Ventricular (LV) ejection fraction ...
Primary cutaneous lymphoma is a type of non-Hodgkin's lymphoma [1]. The primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT) belongs to a subtype of primary cutaneous B-cell lymphoma [2]. The incidence is low, accounting for about 4% of primary cutaneous lymphomas [3], mostly ...
Chronic lymphocytic leukemia (CLL) is the most commonB-cell lymphoproliferative disease. The clinical course of CLL is characterized by heterogeneity, ranging from asymptomatic to aggressive [1]. Some patients surviving for more than 10 years without treatment, whereas others suffer rapid disease...
Primary tumours of cardiac origin are rare even in major heart surgery centres [1]. Atrial myxomas are the most common primary benign tumour of the heart encompassing 50-70% of all cardiac tumours. 75% of atrial myxomas originate from the left atrium and 15-20% originating from the right ...
A 29-year-old man presented with a one-year history of left shoulder pain, which increased with range of motion and further aggravated on gym training. The patient underwent Magnetic Resonance Imaging (MRI) of the shoulder, which revealed significant hypertrophy of the coracohumeral and superior ...
TNF-α is an important cytokine mediator of inflammation and can be induced in response to inflammatory stimuli such as P. gingivalis and LPS in various cell types [1,2]. The regulation of TNF-α gene expression in cells of monocytic lineage is complex and stimulus-dependent, involving controls ...
Pompe's disease is an autosomal recessive inherited disorder that occurs due to a mutation in the GAA gene located on chromosome 17. The gene codes for a lysosomal enzyme called GAA (glucosidase alpha acid) also known as acid maltase. 1% of tertiary neuromuscular centers patients with proximal weakness, ...
The TOR1A gene encodes for Torsin-1A, a member of the AAA family of Adenosine Tri phosphatases (ATPases). This protein participates in several cellular activities, including protein chaperone activities, membrane trafficking, organelle biogenesis and powering cellular proteins [1]. The TOR1A mutations ...
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